INVESTIGATION OF THE KINETICS OF RELEASING OF DECAMETHOXIN ANTIMICROBIC DRUGS FROM MEDICAL APPLICATION POLYMERIC FILMS

Abstract

The main purpose of this work was to investigate the kinetics of releasing of the antiseptic drug decamethoxin from polymeric films to determine the ability of their use in the composition of transdermal therapeutic systems. Methodology. Polymeric films containing polyvinyl alcohol, modified starch, glycerol and antiseptic drug decamethoxin were used in the investigation. For dissolution, water of grade 3 of purity was used. Control of the dissolution samples and the construction of the calibration graphic for DCM was performed spectrophotometrically on the OPTIZEN POP UV VIS device ("Mecasys", South Korea) at a wavelength of 198 nm. The expediency of the use of compositions based on polyvinyl alcohol and modified starch for  obtaining  medical  ilms  has  been  proved.  It  was  established  that the  fastest  release  of  DCM  into  the aqueous phase comes from a polymeric composition film of polyvinyl alcohol / modified starch (3: 1) and
decamethoxin (5%). In this case, the rate constant of the first order is 0.0076 1 / min and it is 3-7 times more than the value of the corresponding rate constants for other investigated polymeric compositions. Originality. The scientific novelty of the work is due to provided mechanical strength of the films and achieved slowdown of sorption-desorption processes of lipophilic drugs through the use of a composition of polymeric materials. The main principle therapeutic systems are built on is regulation of the rate of drug he example of decamethoxin the kinetics of drug release is investigated, kinetic constants for different composition of polymer films are calculated. Practical  value.  Extension  of  the  range  of  therapeutic  transdermal  systems.  The  results  of  the
investigated kinetics of releasing of decamethoxin antiseptic drug, which is part of a polymer film, show that the  proposed  composition  has  prolonged  action  and  provides  an  opportunity  for  use  in  the  treatment  of antiseptic agents and adds new characteristics and benefits.